Dry Skin Treatments – Scientific Rationale | Sharon Rozenblat, PhD, R&D Manager, Kamedis Ltd.

Atopic dermatitis (AD) is a debilitating skin disorder that affects the patients’ quality of life and also their social life. In recent years, the prevalence of skin inflammatory disorders has risen, especially in developing countries. Atopic dermatitis affects 10-30% of the child population and 1-3% of the adult population worldwide. The causes are still unknown, yet the symptoms are well defined: dry irritated skin, itching and inflammation.

The infected areas are usually found on the extremities, such as the inner folds of the knees and arms, as well as the back and thighs.

The skin responds to external and internal environmental changes, including dust, heat, humidity, dry and cold weather, stress and emotional responses. Atopic dermatitis is characterized by a defective skin barrier. Defective skin barrier function leads to increased transepidermal water loss (TEWL) – resulting in increased skin dryness and a reduced anti-microbial barrier, enabling allergens and pathogens to invade the body. The second cause of atopic dermatitis is inflammation due to elevation of TH2 cells, leading to increased production of pro-inflammatory molecules.

The herbal extracts in the Bonatics line are studied in vitro to discover their biological activities. These activities are enhanced by a unique extraction technology that utilizes macro-porous resin chromatography.

One of the prime herbs found in Bonatics products is Da Huang extract (Rheum palmatum). Da Huang extract is known for its anti-inflammatory, anti-allergic and anti-bacterial effects. Bonatics studies found additional anti-inflammatory effects of this extract. Bonatics takes advantage of the herb’s characteristics for the benefit of AD patients.




Da Huang (Rhubarb) - Enrichment of Active Ingredients